| Autor: |
Luis F M, Brígido, Heitor M, Franco, Renata M, Custódio, Carmen A F, Oliveira, João Leandro, P Ferreira, Margareth, Eira, Fernando, Bergel, Fabio, Araújo, Jose R, Carvalheiro, Rosangela, Rodrigues |
| Rok vydání: |
2005 |
| Předmět: |
|
| Zdroj: |
AIDS research and human retroviruses. 21(7) |
| ISSN: |
0889-2229 |
| Popis: |
Partial sequences of HIV-1 polymerase from 185 patients, 141 ARV experienced and 44 naive, of gag (p24) and env (C2V3) from a subset of naive cases were evaluated in São Paulo, Brazil. Antiretroviral resistance mutations were detected in 4% of 26 recently (2 years) infected patients. Polymorphisms at the protease gene were common both in contemporary and pre-HAART era isolates, some significantly associated with the viral clade. HIV-1 clade B was preponderant, in 79%, with 11% clade F and one case of HIV-1 C. Recently infected women had a significantly higher proportion of non-B clade HIV-1. A mosaic pol was observed in 9%, all B/F except for one G mosaic. A CRF-12-BF structure, observed in 20% of B/F pol mosaics, provides evidence for an epidemic relationship in the major South American metropolitan areas. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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