| Autor: |
P R, Schiphof, J A, Vanneste, J E, Ploem |
| Rok vydání: |
1989 |
| Předmět: |
|
| Zdroj: |
Clinical neurology and neurosurgery. 91(4) |
| ISSN: |
0303-8467 |
| Popis: |
We describe a 68-year-old patient with a plasma cell leukaemia in haematological remission presenting with massive intracranial leptomeningeal plasmocytic infiltration (LPI) and hydrocephalus. He was treated with skull irradiation and a combination of intraventricular and lumbar intrathecal therapy with methotrexate. Neurologic improvement and clearance of plasma cells from the cerebrospinal fluid was reached after 2 weeks of treatment but prolonged follow-up was interrupted by a lethal gastro-intestinal haemorrhage, 6 weeks after starting the therapy. From previously reported cases it is known that LPI almost always occurs in either high-grade plasmocytomas or plasma cell leukaemia. These data suggest that therapy of LPI should be the same as in other leukaemias with leptomeningeal infiltration. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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