| Autor: |
V I, Mel'nikova, I I, Khegaĭ, M A, Afanas'eva, L N, Ivanova, L A, Zakharova |
| Rok vydání: |
2013 |
| Předmět: |
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| Zdroj: |
Izvestiia Akademii nauk. Seriia biologicheskaia. (1) |
| ISSN: |
1026-3470 |
| Popis: |
The dynamics of expression of the RT1A antigen of the class I major histocompatibility complex (MHC) in a Walker 256 tumor after its transplantation into Brattleboro rats with a genetic defect of Arginine-Vasopressin synthesis in the hypothalamus was studied. Expression of the RT1A antigen was detected by means of Western-blotting and flow cytometry in the tumor cells on the 14th-17th days after transplantation. In addition, a simultaneous increase in the portion of cells that express the RT1A antigen and in the level of its expression per cell was observed. It is presupposed that at a deficiency of Arginine-Vasopressin, a renewal of expression of the class I MHC antigens, which results in an increase of immunogenicity of this tumor and regression, occurs in the Walker 256 tumor in the Brattleboro rats. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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