| Autor: |
Médea, Padra, John, Benktander, János T, Padra, Anders, Andersson, Bettina, Brundin, Sara, Tengvall, Karin, Christenson, Ingemar, Qvarfordt, Robert, Gad, Magnus, Paulsson, Nikolaos, Pournaras, Anders, Lindén, Sara K, Lindén |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
American journal of respiratory cell and molecular biology. 65(6) |
| ISSN: |
1535-4989 |
| Popis: |
Chronic obstructive pulmonary disease (COPD) is associated with colonization by bacterial pathogens and repeated airway infections, leading to exacerbations and impaired lung function. The highly glycosylated mucins in the mucus lining the airways are an important part of the host defense against pathogens. However, mucus accumulation can contribute to COPD pathology. Here, we examined whether inflammation is associated with glycosylation changes that affect interactions between airway mucins and pathogens. We isolated mucins from lower airway samples ( |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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