Impulsive choices in mice lacking imprinted Nesp55

Autor:	C L, Dent, T, Humby, K, Lewis, A, Plagge, R, Fischer-Colbrie, J F, Wilkins, L S, Wilkinson, A R, Isles
Rok vydání:	2016
Předmět:	Male Serotonin Dopamine DNA Methylation Choice Behavior Epigenesis Genetic Mice Inbred C57BL Genomic Imprinting Mice Impulsive Behavior Chromogranins GTP-Binding Protein alpha Subunits Gs Animals Maternal Inheritance Reinforcement Psychology Alleles
Zdroj:	Genes, brain, and behavior. 15(8)
ISSN:	1601-183X
Popis:	Genomic imprinting is the process whereby germline epigenetic events lead to parent-of-origin specific monallelic expression of a number of key mammalian genes. The imprinted gene Nesp is expressed from the maternal allele only and encodes for Nesp55 protein. In the brain, Nesp55 is found predominately in discrete areas of the hypothalamus and midbrain. Previously, we have shown that loss of Nesp55 gives rise to alterations in novelty-related behaviour. Here, we extend these findings and demonstrate, using the Nesp
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::843afcea3b9dfd1f09c0d344a0e52dc3 https://pubmed.ncbi.nlm.nih.gov/27509352 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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