Wendan decoction improves learning and memory deficits in a rat model of schizophrenia☆

Autor:	Yang, Cuiping, Cai, Changchun, Yang, Xiaojin, Yang, Yanping, Zhou, Zhigang, Liu, Jianhua, Ye, Heping, Wan, Hongjiao
Jazyk:	angličtina
Rok vydání:	2012
Předmět:	Research and Report: Traditional Chinese Medicine and Neural Regeneration schizophrenia Wendan decoction traditional Chinese medicine hippocampus learning and memory neural regeneration Morris water maze long-term potentiation
Zdroj:	Neural Regeneration Research
ISSN:	1876-7958 1673-5374
Popis:	An experimental model of schizophrenia was established using dizocilpine (MK-801). Rats were intragastrically administered with Wendan decoction or clozapine for 21 days prior to establishing the model. The results revealed that the latency of schizophrenia model rats to escape from the hidden platform in the Morris water maze was significantly shortened after administration of Wendan decoction or clozapine. In addition, the treated rats crossed the platform significantly more times than the untreated model rats. Moreover, the rate of successful long-term potentiation induction in the Wendan decoction group and clozapine group were also obviously increased compared with the model group, and the population spike peak latency was significantly shortened. These experimental findings suggest that Wendan decoction can improve the learning and memory ability of schizophrenic rats to the same extent as clozapine treatment.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::832778343e9f94dc3875af9e85141049 http://europepmc.org/articles/PMC4340029 Zobrazit plný text záznamu