| Autor: |
Adam, Varga, Barbara, Sandor, Karoly Kalmar, Nagy, Maria, Viola, Andras, Toth, Katalin, Gombos, Kalman, Toth, Peter, Szakaly |
| Rok vydání: |
2015 |
| Předmět: |
|
| Zdroj: |
In vivo (Athens, Greece). 29(1) |
| ISSN: |
1791-7549 |
| Popis: |
Cardiovascular diseases are a leading cause of mortality after kidney transplantation. According to guidelines, acetylsalicylic acid (ASA) must be given as preventive antiplatelet therapy, but resistance to this drug is also well-known.A total of 214 renal transplant patients were included in our study and took 100 mg of ASA q.d. Aggregometry was performed to determine resistance. Twenty-four variables were examined using logistic regression analysis as possible causes of resistance.ASA resistance was observed in 40.18% of the patients. Resistance reduced concomitant statin therapy and significantly increased simultaneous cyclosporine therapy.Our study assessed the post-transplant ASA resistance in a large population. Clarification of this matter is crutial, since one of the major preventive pharmacological therapies of cardiovascular mortality is not effective in a significant number of patients. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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