Molecular insights into the inhibitory mechanisms of gallate moiety on the Aβ

Autor:	Rong-Zu, Nie, Yin-Qiang, Huo, Bo, Yu, Chuan-Ju, Liu, Rui, Zhou, Hong-Hui, Bao, Shang-Wen, Tang
Rok vydání:	2020
Předmět:	Protein Aggregates Amyloid beta-Peptides Binding Sites Gallic Acid Humans Polyphenols Hydrogen Bonding Molecular Dynamics Simulation Hydrophobic and Hydrophilic Interactions Peptide Fragments Protein Structure Secondary
Zdroj:	International journal of biological macromolecules. 156
ISSN:	1879-0003
Popis:	Alzheimer's disease is the most common form of neurodegenerative disease and the formation of Aβ amyloid aggregates has been widely demonstrated to be the principal cause of Alzheimer's disease. Our previous study and other studies suggested that the gallate moiety played an obligatory role in the inhibition process of naturally occurring polyphenols on Aβ amyloid fibrils formation. However, the detailed mechanisms were still unknown. Thus, in the present study, the gallic acid (GA) was specially selected and the molecular recognition mechanisms between GA molecules and Aβ
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::7d0782c8ca85546482cde37d7621100e https://pubmed.ncbi.nlm.nih.gov/32275992 Zobrazit plný text záznamu Full Text from ScienceDirect