[Experimental studies of the possibilities of radioimmunodetection of cancer of the large intestine by subcutaneous administration of iodinated antibodies to intestinal antigen beta1-MA]

Autor:	S K, Aleksander, L M, Fidler, V V, Mit'kov, K K, Pugachev, G I, Avdeev
Rok vydání:	1990
Předmět:	Male Mice Inbred BALB C Rectal Neoplasms Injections Subcutaneous Mice Nude Antibodies Mice Antigens Neoplasm Injections Intravenous Intestinal Neoplasms Biomarkers Tumor Animals Humans Intestine Large Radionuclide Imaging
Zdroj:	Meditsinskaia radiologiia. 35(4)
ISSN:	0025-8334
Popis:	131I- and 125I-labeled rabbit antibodies (AB) to the specific human intestinal beta 1MA were administered sc and iv to nude mice xenografts of human colon carcinoma. A study was made of the pharmacokinetics of labeled AB in the recipients' organs and tissues, measuring the radioactivity of tissue specimens on days 2, 3, 4 and 7 after injection with a gamma-counter, calculating specific radioactivity and accumulation indices. Tumors were visualized with a gamma-camera and a scanner. Proceeding from the comparison of the results of sc and iv administration of iodinated AB, a conclusion has been made of the applicability of sc injections of the agent for immunoscintigraphy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::7cdeea7da0ef42016694c2f38a536dd6 https://pubmed.ncbi.nlm.nih.gov/2336014 Zobrazit plný text záznamu