Serotonin, suicide, and aggression: clinical studies

Autor: R N, Golden, J H, Gilmore, M H, Corrigan, R D, Ekstrom, B T, Knight, J C, Garbutt
Rok vydání: 1991
Předmět:
Zdroj: The Journal of clinical psychiatry.
ISSN: 0160-6689
Popis: Both suicidal and aggressive, impulsive behaviors have been linked to putative dysregulation in central serotonergic systems. We review data examining the role of serotonin (5-HT) in suicide from postmortem studies and clinical investigations of suicide attempters, including our own preliminary work derived from neuroendocrine challenges with the 5-HT uptake inhibitor clomipramine. Various approaches to the study of 5-HT and aggressive, impulsive behavior, including cerebrospinal fluid studies, investigations of peripheral measures of 5-HT, and neuroendocrine studies utilizing 5-HT probes, are highlighted. Several important caveats, including the challenge of quantifying "suicidality" and "aggression" in reliable and valid ways, should be considered in interpreting the results of clinical studies of 5-HT and suicide and aggression.
Databáze: OpenAIRE