| Autor: |
V F, Ivanova, A A, Puzyrev, R V, Draĭ |
| Rok vydání: |
2011 |
| Předmět: |
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| Zdroj: |
Morfologiia (Saint Petersburg, Russia). 137(6) |
| ISSN: |
1026-3543 |
| Popis: |
The aim of this investigation was to study the structure and regeneration of the endocrine apparatus of the human gastric mucosal glandular epithelium. Using electron microscopy, the mucosal biopsy specimens obtained from 14 patients with chronic erosive Helicobacter pylori-associated gastritis, were studied. The most pronounced changes were seen both in the numbers and ultrastructure of G- and P-endocrinocytes. The changes were detected in the nucleus structure, endocrine granule and polysome content, and he mitochondrial structure. The regeneration of the endocrine cells took place through the differentiation of the committed precursors via the "agranular" cell stage, transformation of the exocrine cells into the endocrine ones, and as a result of the formation of the epithelial cords on the erosion surfaces that consisted of the cells in diverse differentiation stages (from the undifferentiated to specialized cells of all the endocrine and exocrine types). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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