[Relapse of acute promyelocytic leukemia in the central nervous system revealed by isolated dementia]

Autor:	O, Colin, A, Julian, M, Puyade, S, Bouyer, E, Meurin, S, Blondeau, J L, Houeto, J P, Neau
Jazyk:	francouzština
Rok vydání:	2015
Předmět:	Arsenic Trioxide Leukemia Promyelocytic Acute Recurrence Antineoplastic Combined Chemotherapy Protocols Remission Induction Meningeal Neoplasms Humans Dementia Female Oxides Neoplasm Recurrence Local Arsenicals Aged
Zdroj:	La Revue de medecine interne. 37(12)
ISSN:	1768-3122
Popis:	Approximately 1.5% of dementia is due to curable aetiology. We report an isolated dementia syndrome due to a meningeal relapse of acute promyelocytic leukaemia with favourable outcome after appropriate treatment.A 72-year-old woman, in remission of an acute promyelocytic leukaemia, presented a loss of autonomy for several months due to corticosubcortical dementia. Lumbar puncture showed blast cells indicating meningeal relapse of leukaemia. Intrathecal chemotherapy and arsenic trioxide obtained biological and molecular remission as well as restoration of normal cognitive functions.In patients with hematologic past history such as acute promyelocytic leukaemia, an isolated cognitive impairment should alert physicians to search for an isolated neuromeningeal relapse.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::7984733ebf507a5c214833737857e690 https://pubmed.ncbi.nlm.nih.gov/27020402 Zobrazit plný text záznamu Full Text from ScienceDirect