Continuous delivery of naltrexone and nalmefene leads to tolerance in reducing alcohol drinking and to supersensitivity of brain opioid receptors

Autor:	Esa R, Korpi, Anni-Maija, Linden, Heidi R, Hytönen, Nelli, Paasikoski, Elena, Vashchinkina, Mateusz, Dudek, Deron R, Herr, Petri, Hyytiä
Rok vydání:	2015
Předmět:	Alcoholism Disease Models Animal Ethanol Narcotic Antagonists Receptors Opioid Animals Brain Female Naltrexone Rats
Zdroj:	Addiction biology. 22(4)
ISSN:	1369-1600
Popis:	Opioid antagonist treatments reduce alcohol drinking in rodent models and in alcohol-dependent patients, with variable efficacy across different studies. These treatments may suffer from the development of tolerance and opioid receptor supersensitivity, as suggested by preclinical models showing activation of these processes during and after subchronic high-dose administration of the short-acting opioid antagonist naloxone. In the present study, we compared equipotent low and moderate daily doses of naltrexone and nalmefene, two opioid antagonists in the clinical practice for treatment of alcoholism. The antagonists were given here subcutaneously for 7 days either as daily injections or continuous osmotic minipump-driven infusions to alcohol-preferring AA rats having trained to drink 10% alcohol in a limited access protocol. One day after stopping the antagonist treatment, [
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::777e8ee62a4d28ab6020de6a2bbe4e01 https://pubmed.ncbi.nlm.nih.gov/26990998 Zobrazit plný text záznamu Plný text