| Autor: |
Eric J, Devor, Donna A, Santillan, Akshaya, Warrier, Sabrina M, Scroggins, Mark K, Santillan |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
The journal of maternal-fetalneonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. 35(25) |
| ISSN: |
1476-4954 |
| Popis: |
Examine a mechanism of PLAC1 regulation and its potential role in preeclampsia (PE).Placental tissue samples and detailed clinical information were obtained through the University of Iowa Maternal Fetal Tissue Bank (IRB# 200910784) from gestational and maternal age-matched control (PLAC1 expression is seen to be 8.9-fold lower in human placentas affected by preeclampsia in comparison with controls (We confirm that PLAC1 transcription is suppressed in the placentae of women affected by preeclampsia. We further demonstrate that this suppression is driven through the P2 or proximal PLAC1 promoter. This demonstration led to the identification of the MED1-TRAP cofactor complex as the hypoxia-sensitive driver. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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