No major difference in K-ras and p53 abnormalities in sporadic and hereditary nonpolyposis colorectal adenomas
| Autor: | D W, Voskuil, E, Kampman, W, van Geloof, M, Grubben, F, Kok, G, van Muijen, F, Nagengast, H, Vasen, P, van't Veer |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male DNA Mutational Analysis Middle Aged Colorectal Neoplasms Hereditary Nonpolyposis Gene Expression Regulation Neoplastic Proto-Oncogene Proteins p21(ras) Adenomatous Polyps Cell Transformation Neoplastic Case-Control Studies Mutation Humans Female Genetic Predisposition to Disease Tumor Suppressor Protein p53 Colorectal Neoplasms Aged DNA Damage |
| Zdroj: | Digestive diseases and sciences. 45(11) |
| ISSN: | 0163-2116 |
| Popis: | K-ras and p53 gene mutations are known to occur in high frequencies in sporadic colorectal cancers, but findings are inconsistent in hereditary nonpolyposis colorectal cancer (HNPCC). We compared K-ras codon 12 and 13 gene mutations and p53 protein overexpression in 48 HNPCC (positive for Amsterdam criteria) and 59 sporadic colorectal adenomas, to examine whether they may represent similar or different molecular pathways to cancer. In sporadic adenomas K-ras mutations were detected in 32% and p53 overexpression in 31% of the cases. Similarly, K-ras mutations and p53 overexpression were both found in 25% of HNPCC adenomas. The frequencies of these abnormalities were not significantly different between HNPCC and sporadic adenomas. When taking differences in adenoma size into account, the frequencies were even more similar. In conclusion, these results suggest a similar molecular pathway to adenomas in HNPCC and sporadic carcinogenesis, with respect to involvement of K-ras and p53. |
| Databáze: | OpenAIRE |
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