| Autor: |
Stefania, Basili, Lorenzo, Loffredo, Daniele, Pastori, Marco, Proietti, Alessio, Farcomeni, Anna Rita, Vestri, Pasquale, Pignatelli, Giovanni, Davì, William R, Hiatt, Gregory Y H, Lip, Gino R, Corazza, Francesco, Perticone, Francesco, Violi |
| Rok vydání: |
2016 |
| Předmět: |
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| Zdroj: |
International journal of cardiology. 231 |
| ISSN: |
1874-1754 |
| Popis: |
Vascular disease (VD), as assessed by history of myocardial infarction or peripheral artery disease or aortic plaque, increases stroke risk in atrial fibrillation (AF), and is a component of risk assessment using the CHAWe analysed data from the ARAPACIS study, an observational study including 2027 Italian patients with non-valvular AF, in whom CP was detected using Doppler Ultrasonography.VD was reported in 351 (17.3%) patients while CP was detected in 16.6% patients. Adding CP to the VD definition leaded to higher VD prevalence (30.9%). During a median [IQR] follow-up time of 36months, 56 (2.8%) stroke/TIA events were recorded. Survival analysis showed that conventional VD alone did not increase the risk of stroke (Log-Rank: 0.009, p=0.924), while addition of CP to conventional VD was significantly associated to an increased risk of stroke (LR: 5.730, p=0.017). Cox regression analysis showed that VD+CP was independently associated with stroke (HR: 1.78, 95% CI: 1.05-3.01, p=0.0318). Reclassification analysis showed that VD+CP allowed a significant risk reclassification when compared to VD alone in predicting stroke at 36months (NRI: 0.192, 95% CI: 0.028-0.323, p=0.032).In non-valvular AF patients the addition of ultrasound detection of carotid plaque to conventional VD significantly increases the predictive value of CHA |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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