Anatomic patterns of relapse and progression following treatment with

Autor:	Rotem, Fishel Ben Kenan, Alexei L, Polishchuk, Randall A, Hawkins, Steve E, Braunstein, Katherine K, Matthay, Steven G, DuBois, Daphne A, Haas-Kogan
Rok vydání:	2021
Předmět:	Iodine Radioisotopes 3-Iodobenzylguanidine Neuroblastoma Disease Progression Humans Neoplasms Second Primary Neoplasm Recurrence Local Retrospective Studies
Zdroj:	Pediatric bloodcancerREFERENCES. 69(2)
ISSN:	1545-5017
Popis:	Patients with metaiodobenzylguanidine (MIBG)-avid relapsed or refractory neuroblastoma after initial therapy may exhibit transient responses to salvage treatment with iodine-131 metaiodobenzylguanidine (Patients with relapsed or refractory metastatic MIBG-avid neuroblastoma or ganglioneuroblastoma, who received single-agentA total of 84 MIBG-avid metastatic sites were identified immediately prior to MIBG therapy in a cohort of 12 patients. At first progression, a total of 101 MIBG-avid sites were identified, of which 69 (68%) overlapped with pre-treatment disease sites, while 32 (32%) represented anatomically new disease areas. Eight of 12 patients had one or more new MIBG-avid sites at first progression. Of the 69 involved sites at progression that overlapped with pre-treatment disease, 11 represented relapsed sites that had cleared following MIBG therapy, two were persistent but increasingly MIBG-avid, and 56 were stably persistent.Previously involved anatomic disease sites predominate at disease progression following
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::7333ea6ef0bb0e92873707ea7b964b81 https://pubmed.ncbi.nlm.nih.gov/34662499 Zobrazit plný text záznamu Plný text