Progression to AIDS in relation to clinical factors and clotting product consumption. A 14-year follow-up of a cohort of 52 Dutch HIV-1-infected haemophilic patients

Autor:	G, Roosendaal, Y, van der Schouw, E, Mauser-Bunschoten, J, Borleffs, H, van den Berg
Rok vydání:	1999
Předmět:	Adult Acquired Immunodeficiency Syndrome Adolescent Middle Aged Hemophilia A Hemophilia B Blood Coagulation Factors Child Preschool Cytomegalovirus Infections HIV Seropositivity Disease Progression Humans Child Follow-Up Studies
Zdroj:	Vox sanguinis. 75(4)
ISSN:	0042-9007
Popis:	In order to describe the progression of HIV disease in a cohort of Dutch HIV-1-infected patients with haemophilia and to study the influence of clinical and clotting factors, we performed a 15-year longitudinal clinical and laboratory study.The progression to AIDS in relation to type of haemophilia, antibodies against factor VIII, age, cytomegalovirus (CMV) infection, and type and total amount of clotting factor consumption was studied in 52 haemophilic patients infected with HIV-1 between 1981 and July 1985.The progression to AIDS was faster in the group of patients with antibodies against factor VIII (inhibitors) and in the group of patients with haemophilia B than in the group of patients with haemophilia A without inhibitors.We concluded that HIV-infected patients with haemophilia A with inhibitors and patients with haemophilia B show a significantly faster progression to AIDS than do HIV-infected patients with haemophilia A without inhibitors. These differences are independent of the total amount of clotting factor used and other known risk factors such as age at seroconversion and CMV infection and may be due to the type of clotting product used.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::7293d4e200feb69b2667487815645954 https://pubmed.ncbi.nlm.nih.gov/9873260 Zobrazit plný text záznamu Plný text