Development of an antivenom against toxins of Lonomia obliqua caterpillars

Autor:	W D, Da Silva, C M, Campos, L R, Gonçalves, M C, Sousa-e-Silva, H G, Higashi, I K, Yamagushi, E M, Kelen
Rok vydání:	1996
Předmět:	Hemostasis Antivenins Vaccination Hemorrhage Moths Immunohistochemistry Rats Antibody Specificity Drug Design Immunoglobulin G Antibody Formation Animals Horses Blood Coagulation Arthropod Venoms
Zdroj:	Toxicon : official journal of the International Society on Toxinology. 34(9)
ISSN:	0041-0101
Popis:	Skin contact with caterpillars of Lonomia moths causes haemostatic disorders that may evolve into a haemorrhagic syndrome. Replacement therapy has been shown to exacerbate the clinical symptoms of this envenoming. In this study it is shown that horses immunized with a bristle extract of L. obliqua caterpillars produced IgG antibodies that completely neutralized, in vitro, the toxin(s) responsible for the blood incoagulability observed in rats. This antivenom offers the possibility of specific treatment for envenoming caused by contact with caterpillars of Lonomia moths.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::707e279ee086c4e80c2af95454d3402f https://pubmed.ncbi.nlm.nih.gov/8896196 Zobrazit plný text záznamu Full Text from ScienceDirect