| Autor: |
R, Bassan, S, Cortelazzo, A, Rambaldi, P, Cornelli, G, Borleri, P, Bellavita, A, Biondi, T, Barbui |
| Rok vydání: |
1995 |
| Předmět: |
|
| Zdroj: |
Bone marrow transplantation. 15(5) |
| ISSN: |
0268-3369 |
| Popis: |
The prognosis of AML patients who fail autologous BMT and lack a donor for a salvage allogeneic BMT is very poor. We administered an alternative drug treatment including autologous PBSC transplant to a child who relapsed with AML 4 years after a mafosfamide-purged and TBI-containing BMT for second remission AML. Treatment comprised induction-consolidation with 'short' ICE courses (idarubicin-Ara C-etoposide for 2 days), high-dose CY plus G-CSF with collection of CD34+ PBSC and myeloablative treatment with high-dose mitoxantrone/BEAM supported by autologous PBSC reinfusion. The outcome was complete response, lasting 24 months. The patient died in remission of drug-related cardiotoxicity. This report emphasizes the possibility of a secondary AML after mafosfamide-purge autologous BMT, and documents the feasibility of an autologous PBSC transplant in such a high risk setting. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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