| Autor: |
M K, Offermann |
| Rok vydání: |
1999 |
| Předmět: |
|
| Zdroj: |
Journal of acquired immune deficiency syndromes (1999). 21 |
| ISSN: |
1525-4135 |
| Popis: |
Human herpesvirus type 8 (HHV-8) is a recently identified gamma herpesvirus that is associated with and most likely the etiologic agent of Kaposi's sarcoma (KS). Both monocytes and B lymphocytes appear to serve as reservoirs for HHV-8 in asymptomatic individuals, whereas HHV-8 is present in both spindle cells and microvascular endothelial cells within KS lesions. This suggests that a necessary event for the development of KS is infection of endothelial cells with HHV-8. This paper proposes a model for KS in which cellular adhesion molecules are involved in the recruitment of HHV-8-infected leukocytes into KS-prone areas and in which HHV-8-infected cells overcome the antiviral machinery present in endothelial cells. Mechanisms employed by endothelial cells to recognize and contain viral infections are discussed and possible mechanisms employed by HHV-8 to overcome the endothelial antiviral response. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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