[Oral clarithromycin as a treatment option in chronic post-operative endophthalmitis]
| Autor: | F A, Pellegrino, P, Wainberg, A, Schlaen, C, Ortega, P, Bohórquez, F, Bartucci |
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| Rok vydání: | 2005 |
| Předmět: |
Male
Prosthesis-Related Infections Lens Capsule Crystalline Administration Oral Cataract Extraction Lens Implantation Intraocular Clarithromycin Vitrectomy Staphylococcus epidermidis Humans Surgical Wound Infection Propionibacterium acnes Prospective Studies Therapeutic Irrigation Gram-Positive Bacterial Infections Aged Aged 80 and over Endophthalmitis Phacoemulsification Remission Induction Middle Aged Staphylococcal Infections Combined Modality Therapy Treatment Outcome Chronic Disease Female |
| Zdroj: | Archivos de la Sociedad Espanola de Oftalmologia. 80(6) |
| ISSN: | 0365-6691 |
| Popis: | To assess the outcome of medical treatment with oral clarithromycin in patients with chronic post-surgical endophthalmitis.This prospective study was performed between January 1999 and September 2003. Patients with a diagnosis of chronic post-surgical endophthalmitis of bacterial etiology were included. All received 500 mg of oral clarithromycin twice a day for 14 days. The initial and final visual acuity, etiology, post-surgical time of presentation, treatment-delay time, and follow up were recorded. According to the treatment results, patients were distributed into 3 separate groups: 1) complete response, 2) partial response, 3) no response. Data from these groups were compared by means of the Student's t test and Fisher exact test, depending on which was considered most suitable.Fifteen cases of chronic endophthalmitis (11 of Propionibacterium acnes, 4 of Staphylococcus epidermidis) were diagnosed. A complete response was observed in 4 cases, partial response in 4 cases, and no response in 7 cases. Final visual acuity greater than 0.5 was significantly more likely in the complete response group when compared with the no response group (Fisher exact test = 0.0454, p=0.05), however, the same comparison between the complete response group and the partial response group was not significant.Medical treatment with oral clarithromycin could be useful in some patients with chronic post-surgical endophthalmitis. |
| Databáze: | OpenAIRE |
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