| Autor: |
A Y, Jeng, P, Savage, A, Soriano, J L, Balwierczak |
| Rok vydání: |
1990 |
| Předmět: |
|
| Zdroj: |
Biochemistry international. 22(4) |
| ISSN: |
0158-5231 |
| Popis: |
Inhibition of [125I]endothelin-1 ([125I]ET-1) binding to membrane fractions from various rat tissues by ET-1 and endothelin-3 (ET-3) was investigated. Brain tissue demonstrated a 37-fold higher affinity for ET-1 compared to lung, while a greater than 1000-fold difference in affinity for ET-3 was observed in these two tissues. Furthermore, the ratio of the IC50 value of ET-3 to that of ET-1 in each tissue varied from approximately 2 in brain, kidney and liver to greater than 100 in heart and spleen. These experiments show that the tissues examined have different affinities as well as different selectivities for ET-1 and ET-3. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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