| Autor: |
C, Platzer, H, Siakkou, J, Sober, J, Kopp, E, Scheve, S, Rosenthal |
| Rok vydání: |
1990 |
| Předmět: |
|
| Zdroj: |
Acta virologica. 34(3) |
| ISSN: |
0001-723X |
| Popis: |
A panel of newly isolated monoclonal antibodies (MoAbs) is described which are specific for bovine leukaemia virus (BLV) envelope protein gp51. Epitope mapping using competition antibody binding assays and binding studies with gp51-related fusion proteins and synthetic peptides show that they are directed against seven independent antigenic determinants. Four of them are unrelated to the epitopes described earlier (Bruck et al., 1982a). We define three binding regions for the MoAbs on the gp51 molecule. The region between amino acids 170 and 217 is highly immunogenic when the isolated protein is used for immunization, and seems to be inaccessible for immune recognition when gp51 is associated with the virus envelope as it occurs during natural BLV infection. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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