Constitutive downregulation protein kinase C epsilon in hSOD1
| Autor: | Maxime, Vergouts, Pierre J, Doyen, Michael, Peeters, Remi, Opsomer, Emmanuel, Hermans |
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| Rok vydání: | 2017 |
| Předmět: |
Cerebral Cortex
Cations Divalent Amino Acid Transport System X-AG Receptor Metabotropic Glutamate 5 Amyotrophic Lateral Sclerosis Down-Regulation Glutamic Acid Protein Kinase C-epsilon Rats Sprague-Dawley Disease Models Animal HEK293 Cells Superoxide Dismutase-1 Astrocytes Animals Humans Calcium Calcium Signaling Rats Transgenic Cells Cultured |
| Zdroj: | Glia. 66(4) |
| ISSN: | 1098-1136 |
| Popis: | Accumulating evidence indicates that motor neuron degeneration in amyotrophic lateral sclerosis (ALS) is a non-cell-autonomous process and that impaired glutamate clearance by astrocytes, leading to excitotoxicity, could participate in progression of the disease. In astrocytes derived from an animal model of ALS (hSOD1 |
| Databáze: | OpenAIRE |
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