| Autor: |
O Iu, borisova, I K, Mazurova, G A, Ivashinnikova, N T, Gadua, I A, Rudakova, N Ia, Salova, I P, Trebunskikh, V G, Skachkova, R A, Panferova, F, Mooi, V A, Aleshkin |
| Rok vydání: |
2012 |
| Předmět: |
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| Zdroj: |
Zhurnal mikrobiologii, epidemiologii i immunobiologii. (2) |
| ISSN: |
0372-9311 |
| Popis: |
Genotyping of B. pertussis strains isolated from pertussis patients in Moscow.53 strains of B. pertussis isolated from pertussis patients in Moscow in 2007 - 2010 as well as 3 vaccine strains currently used in Russia for the production of DTP vaccine were studied by multilocus sequencing (MLST) based on allele combinations of ptxA, ptxC and tcfA genes.A genetic characteristic of B. pertussis strains isolated from pertussis patients in Moscow by using MLST is presented. Allele profile analysis of the studied B. pertussis strains was performed, 4 sequence types (ST) were identified--ST1, ST2, ST3 and ST5, most of the circulating strains (86.7%) were shown to belong to ST5, equal percentage of cases (5.7%)--to ST2 and ST3, and 1.9%--to ST1, while 2 vaccine production strains belong to ST2 and 1 - to ST1.Clonal structure of contemporary Moscow strains was shown to be different from strain structure used for the production of DTP vaccine. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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