| Autor: |
O, Bostanci, O, Kemik, A, Kemik, M, Battal, U, Demir, S, Purisa, M, Mihmanli |
| Rok vydání: |
2014 |
| Předmět: |
|
| Zdroj: |
European review for medical and pharmacological sciences. 18(17) |
| ISSN: |
2284-0729 |
| Popis: |
Cell adhesion and angiogenesis within the extracellular matrix involve special signaling molecules, such as integrins and the actin binding protein Talin-1. The aim of this study was to investigate and describe the expression of Talin-1 for the early detection of colon cancer.Blood serum samples were collected from 50 healthy volunteers and from 90 patients with colon cancer. Using an enzyme-linked immunosorbent assay (ELISA), all 140 samples were analyzed.Preoperative levels of Talin-1 in the serum were significantly higher in patients with colon cancer (p0.001). No significant correlation was found between preoperative levels of Talin-1 in the serum and the age and gender of the patients (p0.05). However, a significant correlation was found between Talin-1 levels and the tumor grade, TNM stage, and lymph node metastasis (p0.001).Talin-1 may play a role in the reinforcement of cell proliferation, cell adhesion, and angiogenesis in colon cancer. Thus, the Talin-1 protein activity may be a novel biomarker to detect colon cancer in humans. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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