| Autor: |
N, Heinrich, D, Lorenz, H, Berger, K, Fechner, H E, Schmidt, H, Schäfer, B, Mehlis |
| Rok vydání: |
2013 |
| Zdroj: |
Pharmaceutical research. 2(5) |
| ISSN: |
0724-8741 |
| Popis: |
Prolonged release of the peptide gonadotropin-releasing hormone (GnRH) from its aqueous solution was achieved by addition of the polymer dextran (Mw ∼ 500,000). This effect observed in an in vitro system was caused by a decrease of the diffusion coefficient of the peptide. When GnRH was intramuscularly injected into male rats, the addition of dextran to the injected peptide solution led to a prolongation of the GnRH plasma level at the expense of its peak value. This change can be explained by a decrease of the absorption rate of GnRH into blood, which parallels the in vitro observation. As a result, the gonadotropin response to GnRH was stronly increased. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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