| Autor: |
A, Thornton, K N, Tsiquaye, A J, Zuckerman |
| Rok vydání: |
1977 |
| Předmět: |
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| Zdroj: |
British journal of experimental pathology. 58(4) |
| ISSN: |
0007-1021 |
| Popis: |
Several chimpanzees found to be seronegative for hepatitis A by immune electron microscopy and by radioimmunoassay were inoculated with known infective faecal extracts from several sources, including the MS-1 strain of hepatitis A virus, first passage material from chimpanzee George and a strain of hepatitis A virus obtained during a naturally occurring outbreak of infection in Germany. Elevated serum transaminase levels were found in the chimpanzees about 19 days after inoculation. Virus particles were found in faeces as early as 9 days after infection in one chimpanzee and by days 12 and 14 in the others. Excretion of virus continued for 9 to 19 days, and the maximum numbers of virus particles were found on the 17th to the 19th day after inoculation. The buoyant density in caesium chloride of virus particles separated from faeces was 1.31 to 1.43 g/ml. Most of the particles were found in the fraction with a density of 1.34 g/ml. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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