| Autor: |
M S, Saag, G A, Cloud, J R, Graybill, J D, Sobel, C U, Tuazon, P C, Johnson, W J, Fessel, B L, Moskovitz, B, Wiesinger, D, Cosmatos, L, Riser, C, Thomas, R, Hafner, W E, Dismukes |
| Rok vydání: |
1999 |
| Předmět: |
|
| Zdroj: |
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 28(2) |
| ISSN: |
1058-4838 |
| Popis: |
This study was designed to compare the effectiveness of fluconazole vs. itraconazole as maintenance therapy for AIDS-associated cryptococcal meningitis. HIV-infected patients who had been successfully treated (achieved negative culture of CSF) for a first episode of cryptococcal meningitis were randomized to receive fluconazole or itraconazole, both at 200 mg/d, for 12 months. The study was stopped prematurely on the recommendation of an independent Data Safety and Monitoring Board. At the time, 13 (23%) of 57 itraconazole recipients had experienced culture-positive relapse, compared with 2 relapses (4%) noted among 51 fluconazole recipients (P = .006). The factor best associated with relapse was the patient having not received flucytosine during the initial 2 weeks of primary treatment for cryptococcal disease (relative risk = 5.88; 95% confidence interval, 1.27-27.14; P = .04). Fluconazole remains the treatment of choice for maintenance therapy for AIDS-associated cryptococcal disease. Flucytosine may contribute to the prevention of relapse if used during the first 2 weeks of primary therapy. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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