| Autor: |
G, Hayem, P, Chazerain, B, Combe, A, Elias, T, Haim, P, Nicaise, K, Benali, J F, Eliaou, M F, Kahn, J, Sany, O, Meyer |
| Rok vydání: |
1999 |
| Předmět: |
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| Zdroj: |
The Journal of rheumatology. 26(1) |
| ISSN: |
0315-162X |
| Popis: |
To evaluate in various groups of patients with chronic joint disease the sensitivity and specificity of anti-Sa antibody, recently described in sera from adults with rheumatoid arthritis (RA); and to determine the prognostic significance of anti-Sa in initial sera from patients with long standing RA with or without severe joint destruction.Serum samples from 489 patients were included. Of these, 154 were collected from patients with RA attending 2 rheumatology units. Controls were 335 patients with a variety of inflammatory joint diseases other than RA. IgG anti-Sa was detected using an immunoblotting method with purified Sa antigen from human placenta extracts. All patients were tested for the following antibodies: rheumatoid factor (RF), anti-keratin antibody (AKA), antiperinuclear factor (APF), and anti-RA 33. HLA class II DRB alleles were also determined.Anti-Sa was detected in 39.8% of RA sera overall, 46.7% of sera from the long standing RA group, and 23.5% of sera from the recent onset RA group (p0.01). In patients with long standing RA, statistically significant associations were found between the presence of anti-Sa and the following variables: RF (p0.0001), AKA (p0.0001), APF (p0.00001), and HLA DRB1*04 or 01 (p0.01). In contrast, no association was found with anti-RA33. Anti-Sa was positive in 11 adult controls (7.8%) and in 26 pediatric patients with juvenile chronic arthritis (22%). The specificity of anti-Sa for RA was 92.1% in adults with well characterized rheumatic diseases and 85.9% in adults and children together. Among patients with long standing RA, those with destructive disease were more likely to test positive for anti-Sa (66.6%) than those with nondestructive disease (22.2%) (p0.0001). Comparisons with other serologic markers for RA demonstrated that anti-Sa was sensitive (68.4%) and was also the test with the highest specificity (79%), positive predictive value (75%), and negative predictive value (71%) for discriminating between patients who do and those that do not develop late severe radiographic damage.Immunoblot-detected IgG anti-Sa is a sensitive serologic marker for RA patients with severe radiographic damage. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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