Maternal estrogen receptor-beta expression during mouse gestation

Autor:	C Y, Spong, S K, McCune, E M, Sternberg, J A, Gustafsson
Rok vydání:	2000
Předmět:	Base Sequence Uterus Gene Expression Mice Receptors Estrogen Pregnancy Animals Estrogen Receptor beta Pregnancy Animal Female Tissue Distribution RNA Messenger Oligonucleotide Probes In Situ Hybridization
Zdroj:	American journal of reproductive immunology (New York, N.Y. : 1989). 44(4)
ISSN:	1046-7408
Popis:	Although estrogen receptor (ER)-alpha has been well characterized, the recently identified novel ER-beta has not. In some tissues, there is overlap of the ERs, which allows for rescue in cases of deficiency; in other tissues, the ERs appear to have opposite effects. The objective of this study was to evaluate the expression of ER-beta during pregnancy.Pregnant mouse uteri (embryonic days 6-14, 16, 18) were studied. ER-alpha and ER-beta oligonucleotide probes were end-labeled and in situ hybridization histochemistry was performed.ER-beta was strongly expressed in maternal ovaries; there was no other evidence of strong expression during gestation. ER-alpha was expressed in the uterus throughout gestation, with decreasing intensity as gestation progressed, and in maternal ovarian tissue.Differential expression of the two ERs was apparent during pregnancy, with ER-alpha playing a dominant role. This may have implications for selective drug treatment targeting estrogen receptors.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::6324189e642da61c14343ae0ce9e7b62 https://pubmed.ncbi.nlm.nih.gov/11076098 Zobrazit plný text záznamu Plný text