| Autor: |
Olivier, Van Der Meeren, Erik, Jongert, Kelly E, Seaton, Marguerite, Koutsoukos, Annelies, Aerssens, Caroline, Brackett, Muriel, Debois, Michel, Janssens, Geert, Leroux-Roels, Doris, Mesia Vela, Sheetal, Sawant, Nicole L, Yates, Georgia D, Tomaras, Isabel, Leroux-Roels, François, Roman |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Vaccine. 38(7) |
| ISSN: |
1873-2518 |
| Popis: |
Vaccines eliciting protective and persistent immune responses against multiple human immunodeficiency virus type 1 (HIV-1) clades are needed. This study evaluated the persistence of immune responses induced by an investigational, AS01-adjuvanted HIV-1 vaccine as long as 14 years after vaccination.This phase I, open-label, descriptive, mono-centric, extension study with a single group (NCT03368053) was conducted in adults who received ≥3 doses of the clade B gp120-NefTat/AS01At Year 14, positive IgG binding antibody responses were detected in 15 out of the 16 antigens from the BAMA V1V2 breadth panel, with positive response rates ranging from 7.1% to 60.7%. The highest response rates were observed for clade B strain V1V2 antigens, with some level of binding antibodies against clade C strains. Anti-V1V2 IgG3 response magnitude breadth, which correlated with decreased risk of infection in a previous efficacy trial, was of limited amplitude. Response rates to the antigens from the gp120 and gp140 breadth panels ranged from 7.7% to 94.1% and from 15.4% to 96.2% at Year 14, respectively. Following stimulation with gp120 peptide pool, highly polyfunctional gp120-specific CD4+ T-cells persisted up to Year 14, with high frequencies of CD40L tumor necrosis factor alpha (TNF-α), CD40L interleukin-2 (IL-2), CD40L TNF-α IL-2 and CD40L interferon gamma (IFN-γ) TNF-α IL-2 CD4+ T-cells, but no CD8+ T-cells detected.Persistent antibodies binding to HIV-1 envelope glycoproteins, including the V1V2-scaffold, and gp120-specific cellular immunity were observed in volunteers vaccinated 14 years earlier with the gp120-NefTat/AS01 |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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Full Text from ScienceDirect