| Autor: |
Hansol, Lee, Joonsung, Lee, Eunhae, Joe, Seungwook, Yang, Jae Eun, Song, Young-Suk, Choi, Eunkyung, Wang, Chan Gyu, Joo, Ho-Taek, Song, Dong-Hyun, Kim |
| Rok vydání: |
2016 |
| Předmět: |
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| Zdroj: |
Magnetic resonance in medicine. 78(5) |
| ISSN: |
1522-2594 |
| Popis: |
To optimize and investigate the influence of bipolar gradients for flow suppression in metabolic quantification of hyperpolarizedThe trade-off between the amount of flow suppression using bipolar gradients and T2* effect from static spins was simulated. A free induction decay CSI sequence with alternations between the flow-suppressed and non-flow-suppressed acquisitions for each repetition time was developed and was applied to liver tumor-bearing mice via injection of hyperpolarized [1-The in vivo results from flow suppression using the velocity-optimized bipolar gradient were comparable with the simulation results. The vascular signal was adequately suppressed and signal loss in stationary tissue was minimized. Application of the velocity-optimized bipolar gradient to tumor-bearing mice showed reduction in the vessel-derived pyruvate signal contamination, and the average lactate/pyruvate ratio increased by 0.095 (P 0.05) in the tumor region after flow suppression.Optimization of the bipolar gradient is essential because of the short |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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