[Expression of PCNA, BCL-2, CD4+, CD8+ in the adenoid tissues from children with secretory otitis media]

Autor:	Shujun, Zhang, Yuli, Zhang, Zhuoli, Yue, Guiru, Yin, Yingchun, Wang, Qinghong, Li
Rok vydání:	2010
Předmět:	CD4-Positive T-Lymphocytes Male Proto-Oncogene Proteins c-bcl-2 Otitis Media with Effusion Child Preschool Proliferating Cell Nuclear Antigen Adenoids Humans Female CD8-Positive T-Lymphocytes Child
Zdroj:	Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery. 24(16)
ISSN:	2096-7993
Popis:	To investigate the relationship between immune status of adenoids and secretory otitis media (SOM).The adenoid tissue samples of 72 cases with SOM and 30 cases with adenoid hypertrophy without SOM were studied by immunohistochemical method.The PCNA, BCL-2, CD4+, CD8+ and CD4+ / CD8+ in SOM tissue samples were 30.85 +/- 1.73, 21.27 +/- 1.25, 41.90 +/- 9.07, 20.45 +/- 7.08 and 2.10 +/- 0.17, respectively, which were much more than that of tissue samples without SOM (25.25 +/- 1.75, 14.05 +/- 1.02, 16.30 +/- 8.21, 11.15 +/- 5.71, 1.39 +/- 0.15 respectively) (P0.01). The expression of CD4+ in T-lymphocyte was obviously higher than that of CD8+.In adenoid tissues of SOM patients, the activity of T-lymphocyte subsets are increased,the adenoids are enlarged and local immunity are enhanced. Therefore,adenoidectomy should be applied in SOM patients as early as possible.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::60dbb308fba4603b54eb79be83e1cf37 https://pubmed.ncbi.nlm.nih.gov/21033101 Zobrazit plný text záznamu