Distinguishing between primary measles infection and vaccine failure reinfection by IgG avidity assay
| Autor: | R, Hamkar, M, Mahmoodi, R, Nategh, K N, Jelyani, M B, Eslami, T, Mohktari-Azad |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Health Services Needs and Demand Adolescent Measles Vaccine Antibody Affinity Immunization Secondary Urban Health Iran Antibodies Viral Mass Vaccination Diagnosis Differential Immunoenzyme Techniques Age Distribution Immunoglobulin M Measles virus Recurrence Child Preschool Immunoglobulin G Surveys and Questionnaires Humans Treatment Failure Child Measles |
| Zdroj: | Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit. 12(6) |
| ISSN: | 1020-3397 |
| Popis: | In this study in the Islamic Republic of Iran 365 measles cases were evaluated to distinguish between primary infection with measles and reinfection due to secondary vaccine failure. All cases previously confirmed by detection of specific IgM were tested for IgG avidity. A secondary immune response was seen in 18.4% of patients. All unvaccinated patients (16.7%) showed a primary immune response. Of 244 patients with documented vaccination, 75.8% showed a primary immune response and 24.2% showed a secondary immune response, thereby indicating a secondary vaccine failure. Almost all measles reinfections (99%) were seen in patients10 years old, indicating that vaccination for 10-year-old children is recommended. |
| Databáze: | OpenAIRE |
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