| Autor: |
Gui-Lin, Yin, Yan, Li, Ke, Tang, Xiao-Feng, Jin, Xiao-Guang, Chen, Li, Li, Zhi-Qiang, Feng |
| Rok vydání: |
2014 |
| Předmět: |
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| Zdroj: |
Yao xue xue bao = Acta pharmaceutica Sinica. 49(6) |
| ISSN: |
0513-4870 |
| Popis: |
A series of 2-(3-butynoicamidophenyl)benzothiazole derivatives were synthesized starting from 4-fluoro-3-nitrobenzoic acid. Structures of all the synthesized compounds were confirmed by 1H NMR and HR-MS. Their antitumor activities against human tumor cells lines (HCT116, Mia-PaCa2, U87-MG, A549, NCI-H1975) were evaluated by MTT assay. The results revealed that most of the synthesized compounds showed potent activities against HCT116, Mia-PaCa2, U87-MG tumor cells lines. Particularly, compounds 14c and 14h exhibited better activity with IC50 values of 1 x 10(-8) mol x L(-1) against U87-MG and HCT116 respectively. The structure-activity relationship of compounds was also discussed preliminarily. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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