Umifenovir susceptibility monitoring and characterization of influenza viruses isolated during ARBITR clinical study

Autor:	Irina A, Leneva, Irina N, Falynskova, Nailya R, Makhmudova, Artem A, Poromov, Svetlana B, Yatsyshina, Viktor V, Maleev
Rok vydání:	2018
Předmět:	Adult Male Clinical Trials as Topic Indoles Adolescent Microbial Sensitivity Tests Middle Aged Orthomyxoviridae Virus Replication Antiviral Agents Madin Darby Canine Kidney Cells Russia Young Adult Dogs Influenza Human Animals Humans Female Aged
Zdroj:	Journal of medical virology. 91(4)
ISSN:	1096-9071
Popis:	Antiviral drugs can play a significant role in the control of influenza. Umifenovir (Arbidol) is licensed and widely used in Russia for the prophylaxis and/or treatment of influenza. We evaluated the susceptibility to umifenovir of reference influenza A and B viruses and influenza A viruses isolated from patients in the ARBITR clinical trial in 2012-2014 seasons. Using an MDCK cell-based enzyme-linked immunosorbent assay (ELISA), we showed that the replication of antigenically dominant human influenza A and B viruses was efficiently inhibited by umifenovir. The wild-type А/Perth/265/2009 (H1N1)pdm09, A/Fukui/45/2004 (H3N2), and B/Perth/211/2001 viruses and their oseltamivir-resistant counterparts were susceptible to umifenovir among in vitro laboratory assays. All 18 clinical isolates of influenza A viruses obtained before and during therapy were susceptible to umifenovir with 50% effective concentration (EC
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::5f4a67b9d37d87fd23a192696791a28f https://pubmed.ncbi.nlm.nih.gov/30431664 Zobrazit plný text záznamu Plný text