| Autor: |
Marco, Marietta, Massimo, Franchini, M Lucia, Bindi, Francesco, Picardi, Matteo, Ruggeri, Giustina, De Silvestro |
| Rok vydání: |
2015 |
| Předmět: |
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| Zdroj: |
Blood transfusion = Trasfusione del sangue. 14(4) |
| ISSN: |
2385-2070 |
| Popis: |
Only a few studies have compared solvent/detergent plasma (SD-plasma) to standard fresh-frozen plasma (FFP) in terms of efficacy and safety.A systematic review was performed in order to develop a consensus document on the use of SD-plasma. Moreover, a pharmacoeconomic study was performed in order to assess whether the use of SD-plasma can be cost-effective with respect to the use of FFP. A multidisciplinary panel used the systematic review and the GRADE methodology to develop evidence-based recommendations on this topic.Based on moderate to very low quality evidence, the panel developed the following consensus statements: (i) the panel suggested that SD-plasma is safer than FFP; (ii) the panel could not express for or against a greater efficacy of SD-plasma as compared to FFP; (iii) the panel suggested that in patients undergoing liver transplantation SD-plasma can be preferred over FFP; (iv) the panel suggested that SD-plasma can be preferred over FFP in patients with thrombotic thrombocytopenic purpura undergoing plasma-exchange procedures; (v) the panel could not recommend for or against preferring SD-plasma over FFP in critical care patients; and (vi) the panel suggested that the use of SD-plasma can be cost-effective with respect to the use of FFP.Data from additional randomised studies are needed to establish more definitive guidelines on the use of SD-plasma. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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