| Autor: |
R J, Broersma, L W, Kutcher, E F, Heminger, J L, Krstenansky, F N, Marshall |
| Rok vydání: |
1991 |
| Předmět: |
|
| Zdroj: |
Thrombosis and haemostasis. 65(4) |
| ISSN: |
0340-6245 |
| Popis: |
A synthetic hirudin55-65 C-terminal fragment analog was evaluated for anticoagulant activity and in models of experimental thrombosis in mice and rats. Intravenous injection caused dose-related inhibition of thrombin and anticoagulation in rat blood samples, protection from thromboembolism in mice and inhibition of stasis-induced venous thrombosis in rats. Antithrombotic effectiveness corresponded with anticoagulant activity. Anephric animals exhibited longer duration of activity than normal animals suggesting the kidney as a major route of elimination. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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