Role of NOD1 in Heart Failure Progression via Regulation of Ca

Autor: Almudena, Val-Blasco, María Jose G M, Piedras, Gema, Ruiz-Hurtado, Natalia, Suarez, Patricia, Prieto, Silvia, Gonzalez-Ramos, Nieves, Gómez-Hurtado, Carmen, Delgado, Laetitia, Pereira, Gemma, Benito, Carlos, Zaragoza, Nieves, Domenech, María Generosa, Crespo-Leiro, Daniel, Vasquez-Echeverri, Gabriel, Nuñez, Eduardo, Lopez-Collazo, Lisardo, Boscá, María, Fernández-Velasco
Rok vydání: 2016
Předmět:
Zdroj: Journal of the American College of Cardiology. 69(4)
ISSN: 1558-3597
Popis: Heart failure (HF) is a complex syndrome associated with a maladaptive innate immune system response that leads to deleterious cardiac remodeling. However, the underlying mechanisms of this syndrome are poorly understood. Nucleotide-binding oligomerization domain-containing protein 1 (NOD1) is a newly recognized innate immune sensor involved in cardiovascular diseases.This study evaluated the role of NOD1 in HF progression.NOD1 was examined in human failing myocardium and in a post-myocardial infarction (PMI) HF model evaluated in wild-type (wt-PMI) and Nod1The NOD1 pathway was up-regulated in human and murine failing myocardia. Compared with wt-PMI, hearts from Nod1NOD1 modulated intracellular Ca
Databáze: OpenAIRE
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