| Autor: |
D, Wermeling, K, Record, R, Bell, W, Porter, R, Blouin |
| Rok vydání: |
1985 |
| Předmět: |
|
| Zdroj: |
Therapeutic drug monitoring. 7(4) |
| ISSN: |
0163-4356 |
| Popis: |
The hemodialysis clearance of pentobarbital during continuous infusion was determined in a 34-year-old man in acute renal failure. Pentobarbital specimens were obtained simultaneously from arterial blood entering and leaving the dialysis machine at five 1-h intervals. The mean hemodialysis clearance of pentobarbital was 22.3 ml/min. Pentobarbital concentration was relatively unaffected throughout the dialysis period, because of the high dose and continuous infusion of a drug with low hepatic intrinsic clearance and a short dialysis period. A large contribution to total body clearance was not evident, and dosage adjustment would have been unwarranted. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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