| Autor: |
C, Leitzen, S, Herberhold, T, Wilhelm-Buchstab, S, Garbe, T, Müdder, F, Schoroth, H H, Schild, F, Bootz, H, Schüller |
| Jazyk: |
němčina |
| Rok vydání: |
2014 |
| Předmět: |
|
| Zdroj: |
Laryngo- rhino- otologie. 94(6) |
| ISSN: |
1438-8685 |
| Popis: |
Taste dysfunction is a common side effect during irradiation of head and neck. Our aim was to determine the time-dependent course and a possible dependency of this side effect to the radiation-dose during irradiation with helical tomotherapy.31 patients with malignant tumours in the region of head and neck received an IG-/IM-radiotherapy (helical tomotherapy).The median total dose was 63 Gy (range 30-66 Gy). For all patients the subjective taste dysfunction was documented and correlated to the median (D50) tongue dose.A subjective taste dysfunction was registered by the patients themselves after 9 BT (days of radiotherapy) (median). This correlates to a mean dose (D50) of 15.3 Gy (back third of tongue (back ZD)), 11.3 Gy (middle ZD), 8.2 Gy (front ZD). A subjective ageusia occurred after 15 BT (median) (28.9 Gy (back ZD), 22.2 Gy (middle ZD), 17.7 Gy (front ZD)). A starting recovery was registered by 77% of the patients in the first 6-8 weeks after the end of radiotherapy.The time-dependent course of taste dysfunction during radiotherapy and the following recovery is predictable. A dependency of taste dysfunction to radiation-dose exists. Based on the collected data a targeted dose reduction to the tongue with a view to minimize the taste dysfunction is thinkable and aim of further studies. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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