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The extensive use of copper-based nanopesticides in agriculture has led to their release into the aquatic environment and causes a potential risk to aquatic biota. However, there is a lack of knowledge regarding the possible toxic effect of these nanopesticides on non-target aquatic organisms including invertebrates. Therefore, in this study, effects of commonly used copper-based nanopesticide "Kocide 3000" on gene expression related to detoxification (cyp360a8, gst, P-gp, and hr96) and reproductive system (cut, cyp314, dmrt93, and vtg) in Daphnia magna was investigated through an acute toxicity test. In general, exposure to the nanopesticide caused significant down-regulation of detoxification genes after 24 h and then significant up-regulation after 48 h. Exposure to the nanopesticide, however, significantly induced cut expression after 24 h. Moreover, dmrt93 and vtg genes were up-regulated after 48 h exposure to the nanopesticide. On the other hand, the expression of dmrt93 and vtg down-regulated at high concentration of Cu(OH) |
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