| Autor: |
G, Gozlan, L, Lecardeur, A-S, Monfort, M, Doz, I, Ortiz, P, Larroumets, A, Lafuma |
| Jazyk: |
francouzština |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
L'Encephale. 44(6) |
| ISSN: |
0013-7006 |
| Popis: |
The aim of the study was to estimate the cost-effectiveness ratio of aripiprazole once-monthly compared to once-monthly injectable paliperidone palmitate in the treatment of schizophrenia in France on the basis of results and data from the QUALIFY study.Consumed resources data measured with a dedicated questionnaire and results on the quality of life scales from the QUALIFY study were combined with French standard unit costs of each collected consumed resources during QUALIFY to estimate the cost-effectiveness ratios of the two products. Multivariate sensitivity analyses were performed to test the combined impact of the different assumptions.Findings of the study showed greater efficacy on the quality of life (QLS) and psychiatric evaluation scales (CGI-S and CGI-I) observed in QUALIFY of aripiprazole compared with paliperidone palmitate. Findings also suggest a trend (P=0.0733) in the reduction of total costs linked to a statistical decrease (P0,0001) in drug costs in the aripiprazole group. These findings are reinforced by the probabilistic sensitivity analyses.Aripiprazole appeared to be more cost-effective than paliperidone palmitate in the French context. Limits of this study are mainly related with the duration of the clinical trial and to assumptions on the transposability of measured consumed resources in the international clinical trial to the French healthcare system. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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