| Autor: |
Yun, Yang, Zhi-cheng, Huo, Jian, Peng, Man-ying, Jia, Zheng, Huang, Zhi-ming, Wang, Yu-lan, Chen |
| Rok vydání: |
2005 |
| Předmět: |
|
| Zdroj: |
Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA. 25(5) |
| ISSN: |
1000-2588 |
| Popis: |
To evaluate the protective effect of losartan, an angiotensin II type 1 (AT1) receptor antagonist, against myocardial ischemic reperfusion in intact canine.Sixteen dogs were divided into model group(n=8) with left anterior descending coronary artery occlusion for 30 min followed by reperfusion for 30 min and losartan group (n=8) with 5 mg/(kg x d) intragastric losartan administration for 2 weeks before the ischemic-reperfusion model establishment. Monophasic action potential recording technique was employed to observe the incidence of early after depolarization (EAD) and reperfusion arrhythmias.In the model group, 5 dogs (62.5%) developed EAD and reperfusion arrhythmia while 3 (37.5%) developed the symptoms in losartan group, showing significant difference between the two groups (P0.05). No ventricular tachycardia or ventricular fibrillation was observed in losartan group (P0.01).Losartan can suppress the occurrence of EAD during reperfusion following myocardial ischemia to reduce the incidence of reperfusion arrhythmias, suggesting its protective effect against myocardial ischemic injury. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
