Exploring functional interplay amongst

Autor: James A, Goetz, Noah M, Kuehfuss, Alexander J, Botschner, Shawna, Zhu, Laura K, Thompson, Georgina, Cox
Rok vydání: 2022
Předmět:
Zdroj: Microbiology (Reading, England). 168(11)
ISSN: 1465-2080
Popis: Bacterial efflux pumps exhibit functional interplay that can translate to additive or multiplicative effects on resistance to antimicrobial compounds. In diderm bacteria, two different efflux pump structural types - single-component inner membrane efflux pumps and cell envelope-spanning multicomponent systems - cooperatively export antimicrobials with cytoplasmic targets from the cell. Harnessing our recently developed efflux platform, which is built upon an extensively efflux-deficient strain of
Databáze: OpenAIRE