Functional and structural characterization of anti-beta1-adrenoceptor autoantibodies of spontaneously hypertensive rats
| Autor: | Gerd, Wallukat, Svenia, Podlowski, Eberhard, Nissen, Rosemarie, Morwinski, Csaba, Csonka, Arpad, Tosaki, Ingolf E, Blasig |
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| Rok vydání: | 2003 |
| Předmět: |
Aging
Adrenergic beta-Antagonists Immunoglobulins Blood Pressure Thionucleotides Rats Inbred WKY Rats Propanolamines Epitopes Animals Newborn Heart Rate Rats Inbred SHR Cyclic AMP Ventricular Pressure Animals Humans Myocytes Cardiac Receptors Adrenergic beta-1 Cardiomyopathies Peptides Cells Cultured Autoantibodies Signal Transduction |
| Zdroj: | Molecular and cellular biochemistry. 251(1-2) |
| ISSN: | 0300-8177 |
| Popis: | Eighteen month old spontaneously hypertensive rats (SHR-rats) showed myocardial dysfunction and autoantibodies directed against the beta1-adrenoceptor similarly as known in human dilated cardiomyopathy or Chagas' disease. The agonist-like antibodies were able to activate the beta1-adrenoceptor mediated signal transduction cascade in cultured rat cardiomyocytes and induced a long-lasting stimulatory effect resulting in a harmful adrenergic overdrive. The antibodies recognized an epitope of the second extracellular loop of the beta1-adrenoceptor identical to that epitope identified in Chagas' disease. In conclusion, our assumption is supported that old SHR-rat are an useful animal model for investigating the role of anti-beta1-adrenoceptor antibodies in the induction of human cardiomyopathy. |
| Databáze: | OpenAIRE |
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