[Detection of t(3 ; 21) (q26 ; q22) with AML1/EVI1 mRNA during progression of myelodysplastic syndrome to acute myeloid leukemia]
| Autor: | I, Choi, T, Goto, M, Nagano, K, Muta, Y, Yufu, N, Uike, M, Kozuru, Y, Abe, J, Nisimura |
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| Rok vydání: | 1999 |
| Předmět: |
Chromosomes
Human Pair 21 Recombinant Fusion Proteins Translocation Genetic DNA-Binding Proteins Leukemia Myeloid Myelodysplastic Syndromes Proto-Oncogene Proteins Acute Disease Core Binding Factor Alpha 2 Subunit Disease Progression Humans Female Chromosomes Human Pair 3 RNA Messenger Aged Transcription Factors |
| Zdroj: | [Rinsho ketsueki] The Japanese journal of clinical hematology. 40(6) |
| ISSN: | 0485-1439 |
| Popis: | A 74-year-old woman had myelodysplastic syndrome (MDS) in 1986. In June 1994, she suffered exacerbation of pancytopenia with no chromosomal abnormalities, but AML1/EVI1 chimeric mRNA was detected by RT-PCR. Two months later, an increase in bone marrow blasts (5%) was noted, and chromosomal analysis detected t(3 ; 21) (q26 ; 22), del(7) (q22), del(11) (q23). In 1995, the marrow blasts increased to 30% and the patient died of disease progression. The AML1/EVI1 gene has been shown to cause blast crisis in chronic myelogenous leukemia. This case suggested that the AML1/EVI1 gene may be involved in the progression of MDS together with del(7) (q22) and del(11) (q23). |
| Databáze: | OpenAIRE |
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