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Despite current research in the development of drugbased cytostatic and targeted therapies in the treatment of breast cancer, radiation therapy (RT) is an important component in the treatment of this pathology in the postoperative period. At the same time, an important problem is the development of pathological changes in the heart in the longterm period, which worsen the quality of life and increase the risk of cardiac death 10 or more years after RT The problem of heart damage due to RT is gaining new significance due to the existing increase in the number of cancer patients requiring radiation exposure in the modern world. RT of malignant tumors of the breast and organs of the chest cavity causes damage to all structures of the heart, including the coronary arteries, valves, conducting system, pericardium. The frequency of heart damage increases in proportion to the time that has passed after RT. According to some authors, the prevalence of clinically significant radiationinduced heart diseases 5-10 years after RT is 10-30%, and the frequency of asymptomatic lesions is 88%. The duration of the latent period can reach 15-20 years. The work has an analysis of longterm studies of the presence of pathological changes that are found in the heart tissues of patients with breast cancer, as a result of radiation therapy.Nezvazhaiuchy na suchasni doslidzhennia v rozvytku medykamentoznoï tsytostatychnoïi targetnoïterapiï v likuvanniraku molochnoï zalozy, promeneva terapiia (PT) ie vazhlyvym komponentom u likuvanni danoï patologiï v pisliaoperatsiĭnomu periodi. Pry ts'omu vazhlyvoiu problemoiu ie rozvytok patologichnykh zmin sertsia u viddalenomu periodi,vony pogirshuiut' iakist' zhyttia i pidvyshchuiut' ryzyk sertsevoï smerti cherez 10 i bil'she rokiv pislia PT. Problemaurazhennia sertsia vnaslidok provedennia PT otrymuie nove znachennia u zv’iazku z isnuiuchym zbil'shenniam v suchasnomu sviti kil'kosti onkologichnykh patsiientiv, iaki potrebuiut' diï oprominennia. PT zloiakisnykh pukhlyn molochnoï zalozy ta organiv grudnoï porozhnyny vyklykaie urazhennia vsikh struktur sertsia, vkliuchaiuchy koronarni arteriï, klapany, providnu systemu, perykard. Chastota urazhennia sertsia zrostaie proportsiĭno chasu, shcho proĭshov pislia PT. Rozpovsiudzhenist' klinichno znachushchykh radiatsiĭno indukovanykh zakhvoriuvan' sertsia za danymy deiakykh avtoriv cherez5–10 rokiv pislia PT stanovyt' 10–30 %, a chastota bezsymptomnykh urazhen' 88 %. Tryvalist' latentnogo periodumozhe dosiagaty 15–20 rokiv. V roboti nadano analiz bagatorichnykh doslidzhen' naiavnosti patologichnykh zmin, iakivyiavliaiut' v tkanynakh sertsia u khvorykh na rak molochnoï zalozy iak naslidok provedennia promenevoï terapiï. |
